Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the App NL-GF-/NL-G-F knock-in mouse model of Alzheimer’s disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior.
Neuroscience Research 177, 118-134 (2022)
中別府雄作先生（九州大学）との共同研究成果