2023年 Proteomic alterations in the brain and blood-brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease.
Fluids and Barriers of the CNS 20, 66 (2023)
2023年 A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury.
Science Translational Medicine 15, eabo6889 (2023)
Zhuohao He先生(University of the Chinese Academy of Sciences)との国際共同研究成果
2023年 Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Nature Communications 14, 5247 (2023)
David Owen先生(Imperial College London)との国際共同研究成果
2023年 A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.
Cell Reports Methods 3, 100532 (2023)
Julija Krupic先生(University of Cambridge)との国際共同研究成果
2023年 Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL-G-F/NL-G-F mice.
Frontiers in Aging Neuroscience 15, 1211067 (2023)
森 寿先生(富山大)との共同研究成果
2023年 Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer’s disease.
Neurobiology of Disease 184, 106219 (2023)
Agnieszka Basta-Kaim先生(Polish Academy of Sciences, Poland)との国際共同研究成果
2023年 Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease.
Nature 618, 349-357 (2023)
Klaus-Armin Nave先生(Max Planck Institute for Multidisciplinary Sciences, Germany)との国際共同研究成果
2023年 Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal – medial prefrontal cortex circuit during natural sleep in AppNL-G-F mice.
Neurobiology of Disease 182, 106151 (2023)
Michael Craig先生(University of Exeter Medical School)との国際共同研究成果
2023年 Exposure to quasi-ultrafine particulate matter accelerates memory impairment and AD neuropathology in the AppNL-G-F knock-in mouse model.
Toxicological Sciences 193, 175-191 (2023)
Masashi Kitazawa先生(UC Irvine)との国際共同研究成果
2023年 A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation.
Communication Biology 6, 383 (2023)
2023年 INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.
iScience 26, 106375 (2023)
2023年 Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer’s amyloid β-peptide.
EMBO Molecular Medicine e17052 (2023)
2023年 Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL-F/NL-F knock-in mouse model of Alzheimer’s disease.
Alzheimer’s Research & Therapy 15, 64 (2023)
Oskar Hasson先生(Lund University, Sweden)との国際共同研究成果
2023年 Brain-derived major glycoproteins are possible biomarkers for altered metabolism of cerebrospinal fluid in neurological diseases.
International Journal of Molecular Sciences 24, 6084 (2023)
2023年 Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease.
Inflammation and regeneration 43, 20 (2023)
2023年 Reduced autophagy in aged trigeminal neurons causes amyloid β diffusion.
Journal of Dental Research 220345231156095 (2023)
2023年 The senile plaque: Morphological differences in APP knock-in mice brains by fixatives.
Brain and Behavior 13, e2953 (2023)
2023年 Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice.
Nature Communications 14, 802 (2023)
Jongpil Kim先生(Dongguk University, Korea)との国際共同研究成果
2023年 肱岡、眞鍋、斉藤による総説”Multifactorial glial responses and their contributions to AD continuum“がClinical & Experimental Neuroimmunology 14, 82-91 (2023)に掲載されました。こちらからDLできます。
2023年 Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer’s disease.
Frontiers in Aging Neuroscience 14, 1085989 (2023)
Alex D Leow先生(University of Illinois)との国際共同研究成果
2023年 Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.
Scientific Reports 13, 1109 (2023)
2023年 Accumulation of amyloid-β in the brain of mouse models of Alzheimer’s disease is modified by altered gene expression in the presence of human apoE isoforms during aging.
Neurobiology of Aging 123, 63-74 (2023)
2023年 Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathologica 145, 325-333 (2023)
Michel Goedert先生(MRC)との国際共同研究成果
2022年 BAG3 attenuates tau hyperphosphorylation and gliosis induced by traumatic brain injury.
Alzheimer’s & Dementia 18, e066654 (2023)
Hongjun Fu先生(The Ohio State University)との国際共同研究成果
2022年 Impairment in novelty-promoted memory via behavioral tagging and capture before apparent memory loss in a knock-in model of Alzheimer’s disease.
Scientific Reports 12, 22298 (2022)
Szu‑Han Wang先生(University of Edinburgh)との国際共同研究成果
2022年 G protein–biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model.
PNAS 119, e2204828119 (2022)
Amantha Thathiah先生(University of Pittsburgh)との国際共同研究成果
2022年 CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease.
Translational Neurodegeneration 11, 41 (2022)
Jongpil Kim先生(Dongguk University, Korea)との国際共同研究成果
2022年 Multifunctional therapeutic cyclodextrin-appended dendrimer complex for treatment of systemic and localized amyloidosis.
ACS Applied Materials & Interfaces 14, 40599-40611 (2022)
2022年 Age-dependent behavioral and metabolic assessment of AppNL-G-F/NL-G-F knock-in (KI) mice.
Frontiers in Molecular Neuroscience 15, 909989 (2022)
Brian Head先生(University of California, San Diego)との国際共同研究成果
2022年 β-secretase inhibition prevents structural spine plasticity deficits in AppNL-G-F mice.
Frontiers in Aging Neuroscience 14, 909586 (2022)
Jochen Herms先生(German Center for Neurodegenerative Diseases, Munich)との国際共同研究成果
2022年 Hippocampal neural circuit connectivity alterations in an Alzheimer’s disease mouse model revealed by monosynaptic rabies virus tracing.
Neurobiology of Disease 105820 (2022)
Xiangmin Xu先生(University of California, Irvine)との国際共同研究成果
2022年 Genetic mapping of APP and amyloid-β biology modulation by trisomy 21.
Journal of Neuroscience JN-RM-0521-22 (2022)
Elisabeth Fisher先生、Frances Wiseman先生(University College London)との国際共同研究成果
2022年 Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain.
Journal of Biochemistry 172, 233-243 (2022)
2022年 Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models.
Acta Neuropathologica Communications 10, 99 (2022)
Paul Morgan先生(Cardiff University)との国際共同研究成果
2022年 Expression of transferrin protein and messenger RNA in neural cells from mouse and human brain tissue.
Metabolites 12, 594 (2022)
2022年 14-3-3θ does not protect against behavioral or pathological deficits in Alzheimer’s disease mouse models.
eNeuro ENEURO.0368-21.2022 (2022)
Talene A Yacoubian先生(University of Alabama)との国際共同研究成果
2022年 Early memory deficits and extensive brain network disorganization in the AppNL-F/MAPT double knock-in mouse model of familial Alzheimer’s disease.
Aging Brain 2, 100042 (2022)
Chantal Mathis先生(University of Strasbourg, France)との国際共同研究成果
2022年 An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities
Science Advances 8, eabm6155(2022)
理研・西道研究室での成果。AppNL-G-F KIマウスからゲノム編集によりNL(Swedish)変異を取り除いたマウスを新たに開発しました。
2022年 Propolis promotes memantine-dependent rescue of cognitive deficits in APP-KI mice
Molecular Neurobiology 59, 4630-4646 (2022)
2022年 Effects of high-fat diet on nutrient metabolism and cognitive functions in young APPKI NL-G-F/NL-G-F mice
Neuropharmacology Reports 42, 272-280 (2022)
2022年 Expression of olfactory-related genes in the olfactory epithelium of an Alzheimer’s disease mouse model
Journal of Alzheimers Disease 88, 29-35 (2022)
2022年 Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer’s disease
Biochemical and Biophysical Research Communications 610, 85-91 (2022)
2022年 High correlation among brain-derived major protein levels in cerebrospinal fluid: Implication for Amyloid-beta and Tau protein changes in Alzheimer’s disease
Metabolites 12, 355 (2022)
2022年 Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged AppNL-G-F/NL-G-F mice
Molecular Brain 15, 32 (2022)
2022年 Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice
Journal of Biological Chemistry 101880 (2022)
2022年 AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer’s disease model.
EMBO Molecular Medicine e09824 (2022)
Matthew Holt先生(VIB-KU Leuven, Belgium)との国際共同研究成果
2022年 Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.
Molecular Psychiatry 27, 3024-3033 (2022)
Patricia Salinas先生(University College London)との国際共同研究成果
2022年 Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease.
Seminars in Cell and Developmental Biology S1084-9521(22)00068-4 (2022)
Afia Ali先生(University College London)との国際共同研究成果
2022年 Recent advances in the modeling of Alzheimer’s disease.
Frontiers in Neuroscience e807473 (2022)
最近のアルツハイマー病モデルマウスについてまとめました。西道チーム(理研)、長崎大、早稲田大、理研BRC、実中研、Karolinska Institute (Sweden)らの国際チームで書き上げた総説です。斉藤もco-corresponding authorになっています。
2022年 Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease.
iScience 25, 103869 (2022)
2022年 Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.
Scientific Reprots 12, 1796 (2022)
Erik Musiek先生(Washington University)との国際共同研究成果
2022年 11 C-PIB and 124 I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention.
Journal of Nuclear Medicine 63, 302-309 (2022)
Stina Syvanen先生(Uppsala大学)との国際共同研究成果
2022年 Periodontal infection aggravates C1q-mediated microglial activation and synapse pruning in Alzheimer’s mice.
Frontiers in Immunology 13, 816640 (2022)
Ping Zhang先生(Univ. of Alabama)との国際共同研究成果
2022年 Lipoxin A4 receptor stimulation attenuates neuroinflammation in a mouse model of intracerebral hemorrhage.
Brain Science 16, 162 (2022)
肱岡助教が、前所属(北村佳久先生・立命館大)から継続してきた研究成果をcorresponding authorとしてまとめました!
2022年 Disrupted neural correlates of anesthesiaand sleep reveal early circuitdysfunctions in Alzheimer models.
Cell Reports 38, 110268 (2022)
Inna Slutsky先生(Tel Aviv University, Israel)との国際共同研究成果
2022年 Therapeutic effects of anti‑amyloid β antibody after intravenous injection and efficient nose‑to‑brain delivery in Alzheimer’s disease mouse model.
Drug Delivery and Translational Research 12, 2667-2677 (2022)
2022年 Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the App NL-GF-/NL-G-F knock-in mouse model of Alzheimer’s disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior.
Neuroscience Research 177, 118-134 (2022)
2022年 Assessing sex-specific circadian, metabolic, and cognitive phenotypes in the AβPP/PS1 and AppNL-F models of Alzheimer’s Disease.
Journal of Alzheimer’s Disease 85, 1077-1093(2022)
Erin Hascup先生(Southern Illinois University School of Medicine)との国際共同研究成果
2022年 Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway.
Molecular Psychiatry 27, 1816-1828 (2022)
理研・西道研究室の綿村直人研究員による報告です。Nature Medicine 2005の後継研究として展開し、AMED脳プロの支援を受け、長い時間コツコツとデータを積み上げた玉稿になりました。Karolinska Institute (Sweden)含めた国際共同研究成果です。
2021年 MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease.
Oxidative Medicine and Cellular Longevity 2021, 8635088 (2021)
2021年 Amelioration of Alzheimer’s disease by Gut-Pancreas-Liver-Brain interaction in an App knock-in mouse model.
Life 12, 34 (2021)
2021年 Microglia-based sex-biased neuropathology in early-stage Alzheimer’s Disease model mice and the potential parmacologic efficacy of Dioscin.
Cells 10, 3261 (2021)
東華岳先生(産業医科大)とTianjin Universityとの国際共同研究成果
2021年 Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in App NL-G-F, App NL-F, and 3xTg-AD mouse models.
Genome Medicine 13, 168 (2021)
Patrick Aloy先生(ICREA, Spain)との国際共同研究成果
2021年 Kaempferol has potent protective and antifibrillogenic effects for α-synuclein neurotoxicity in vitro.
International Journal of Molecular Science 22, 11484 (2021)
2021年 HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology.
Communication Biology 4, 1175 (2021)
岡澤均先生(東京医科歯科大)、Marco E Bianchi先生(IRCCS San Raffaele Scientific Institute, Italy)との国際共同研究成果
2021年 Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease.
Elife 10, e71879 (2021)
Christiane Ruedl先生(Nanyang Technological University, Singapore)との国際共同研究成果
2021年 Transferrin biosynthesized in the brain is a novel biomarker for Alzheimer’s disease.
Metabolites 11, 616 (2021)
2021年 Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid.
Journal of Neurochemistry 159, 603-617 (2021)
2021年 Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease.
Cell Death & Disease 12, 769 (2021)
Daniele Zacchetti先生(IRCCS San Raffaele Scientific Institute, Italy)との国際共同研究成果
2021年 A 3rd generation mouse model of Alzheimer’s disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.
Journal of Biological Chemistry 297, 101004 (2021)
2021年 Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia.
Molecular Neurodegeneration 16, 47 (2021)
Damian Cummings先生、Frances Edwards先生(University College London)との国際共同研究成果
2021年 A high-fat diet exacerbates the Alzheimer’s disease pathology in the hippocampus of the App NL-F/NL-F knock-in mouse model
Aging Cell e13429 (2021)
2021年 Neuronal cell cycle re-entry enhances neuropathological features in AppNLF knock-in mice.
Journal of Alzheimer’s Disease 82, 1683-1702 (2021)
Kevin Park先生(Central Michigan University)との国際共同研究成果
2021年 Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis.
Journal of Alzheimer’s Disease 82, 1513-1530 (2021)
2021年 Modality specific impairment of hippocampal CA1 neurons of Alzheimer’s disease model mice.
Journal of Neuroscience 41, 5315-5329 (2021)
2021年 Difference in the malignancy between RAS and GLI1-transformed astrocytes is associated with frequency of p27 KIP1-positive cells in xenograft tissues.
Pathology Research & Practice 223, 153465 (2021)
2021年 Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease.
Scientific Reports 11, 7289 (2021)
山本健先生、矢野雅文先生(山口大学)、Xiaojuan Xu先生(Tongji University)との国際共同研究成果
2021年 PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey.
Journal of Cerebral Blood Flow & Metabolism 41, 2410-2422 (2021)
Xiaoyun Xhou先生、樋口真人先生(量研機構・放医研)との共同研究成果
2021年 Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Molecular Neurodegeneration 16, 18 (2021)
Tsuneya Ikezu先生(Boston University/Mayo Clinic)との国際共同研究成果
2021年 Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer’s Disease.
Journal of Alzheimer’s Disease 80, 1687-1704 (2021)
2021年 Early Identification of Alzheimer’s Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters.
iScience 24, 102198 (2021)
2021年 Distinct microglial response against Alzheimer’s amyloid and tau pathologies characterized by P2Y12 receptor.
Brain Communications 3, fcab011 (2021)
佐原成彦先生、樋口真人先生(量研機構・放射線医学総合研究所)、Univ. Pennsylvaniaとの国際共同研究成果
2021年 Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in App NL-G-F, App NL-F, and wild type mice.
Scientific Reports 11, 4678 (2021)
Jacob Raber先生(Oregon Health & Science University)との国際共同研究成果
2021年 Multi-scale network imaging in a mouse model of amyloidosis.
Cell Calcium 95, 102365 (2021)
Samuel Barnes先生(Imperial College London)との国際共同研究成果
2021年 Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.
Journal of Alzheimer’s Disease 80, 159-174 (2021)
西村正樹先生(滋賀医大)、Lei Liu先生(Harvard Medical School)との国際共同研究成果
2021年 Retinal thickness changes over time in a murine AD model APPNL-F/NL-F.
Frontiers in Aging Neurosciene 12, 625642 (2021)
Maria Moro先生(Complutense University of Madrid)との国際共同研究成果
2021年 The App NL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research.
Acta Neuropathologica Communications 8, 6 (2021)
Lies De Groef先生(KU Leuven)との国際共同研究成果
2021年 Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease.
Acta Neuropathologica Communications 9, 1 (2021)
2021年 A potential defense mechanism against amyloid deposition in cerebellum.
Biochemical and Biophysical Research Communications 535, 25-32 (2021)
2021年 Early-life stress induces the development of Alzheimer’s disease pathology via angiopathy.
Experimental Neurology 337, 113552 (2021)
2021年 Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Cell Systems 12, 141-158 (2021)
Jeffrey Savas先生(Northwestern University)との国際共同研究成果
2020年 Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease.
Molecular Brain 13, 147 (2020)
2020年 Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer’s Disease.
Nutrients 12, 3248 (2020)
Natasja de Bruin先生(Fraunhofer Institute for Molecular Biology and Applied Ecology)との国際共同研究成果
2020年 Gene-environment interaction promotes Alzheimer’s risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.
Neurobiology of Disease 145, 105059 (2020)
Stephen Strittmatter先生(Yale Univ)との国際共同研究成果
2020年 Prodromal Alzheimer’s Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer’s Pathology.
Frontiers in Neuroscience 14, 562581 (2020)
Carols Dotti先生(CSIC/UAM)との国際共同研究成果
2020年 The two faces of synaptic failure in App NL-G-F knock-in mice.
Alzheimer’s Research & Therapy 12, 100 (2020)
Detlef Balschun先生(KU Leuven, Belgium)との国際共同研究成果
2020年 Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer’s Disease.
Neuron 107, 1095-1112 (2020)
五十嵐啓先生(UC Irvine)との国際共同研究成果
2020年 Analysis of taste sensitivities in App knock-in mouse model of Alzheimer’s disease.
Journal of Alzheimer’s disease 76, 997-1004 (2020)
2020年 Fibrillar Aβ Triggers Microglial Proteome Alterations and Dysfunction in Alzheimer Mouse Models.
eLife 9, e54083 (2020)
Sabina Tahirovic先生、Jochen Herms先生、Christian Haass先生ら(DZNE)との国際共同研究成果
2020年 Amyloid β Induces Interneuron-Specific Changes in the Hippocampus of APPNL-F Mice.
PLoS One 15, e0233700 (2020)
Gábor Nyiri先生(HAS, Hungary)との国際共同研究成果
2020年 Versatile whole-oragan/body staining and imaging based on electrolyte-gel properties of biological tissues.
Nature Communications 11, 1982 (2020)
2020年 Progressive changes in sleep architecture and electroencephalogram in single App knock-in mice and its relations to amyloid-β distribution and learning abilities.  
eNeuro 7: ENEURO.0093-20.2020(2020)
林 悠先生(筑波大学→現・京都大学)との共同研究成果
2020年 Proteomics time-course study of APP knock-in mice reveals novel presymptomatic Aβ42-induced pathways to Alzheimer pathology.
Journal of Alzheimer’s disease 75, 321-335 (2020)
Per Nilsson先生、Lars Tjernberg先生(Karolinska Institute)との国際共同研究成果
2020年 Oral glutathione administration inhibits the oxidative stress and the inflammatory responses in AppNL−G-F/NL−G-F knock-in mice.
Neuropharmacology 163, 108026 (2020)
2020年 Astaxanthin ameliorated parvalbumin-positive neuron deficits and Alzheimer’s disease-related pathological progression in the hippocampus of AppNL-G-F/NL-G-F mice.
Frontiers in Pharmacology 11, Article 307 (2020)
2020年 YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology.
Nature Communications 11, 507, (2020)
2020年 β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.
Science Translational Medicine 12 (526) (2020)
Qin Wang先生(University of Alabama)との国際共同研究成果
2020年 Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-in Alzheimer’s Disease Model Mice.
Molecular Cell Biology pii: MCB.00467-19 (2020)
2020年 Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model.
Molecular Neurodegeneration 15, 3 (2020)
Bart De Strooper先生(KU Leuven)との国際共同研究成果
2020年 Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
FASEB J 34, 2425-2435 (2020)
2019年 Biology of splicing in Alzheimer’s disease research.
Progress in Molecular Biology and Translational Science 168, 79-84, 2019
2019年 ABCA7 haplodeficiency disturbs microglial immune responses in the mouse model. 
Proc Natl Acad Sci USA 116, 23790-23796 (2019)  
Takahisa Kanekiyo先生(Mayo Clinic)との国際共同研究成果
2019年 Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer’s disease.
Neurobiology of Disease 10463 (2019)
2019年 An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain. 
Journal of Neuroinflammation 16, 173 (2019)
2019年 Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules. 
Nanomedicine 14, 2409-2422 (2019)
Carlos Dotti先生(CBM Severo Ochoa)との国際共同研究成果
2019年 Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours.
Disease Model and Mechanisms 12, dmm.040550 (2019)
James Dachtler先生(University of Leeds)との共同研究成果
2019年 Serine phosphorylation of IRS1 correlates with Aβ-unrelated memory deficits and elevation in Aβ level prior to the onset of memory decline in AD.
Neutrients 11, 1942 (2019)
2019年 Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation. 
Journal of Biological Chemistry 294, 12754-12765 (2019). (*Corresponding author)  
斉藤が理化学研究所・西道研究室で行った成果がまとまりました。マウスの開発をはじめてから9年の歳月をかけた結晶です! マウスMapt遺伝子部位にヒトMAPT遺伝子を置き換えたことで、マウス脳内にヒトMAPT (Tau)の 全てのisoformsが発現するようになりました(マウスTauのヒト化に成功:MAPT knockinマウスの完成)。当該マウスにアルツハイマー病患者由来のTauの凝集体を注入すると、野生型マウスよりもより早くTau病理の伝播が認められました。App knockinマウスと併せて有用な研究リソースとして提供しています。
2019年 Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes.
Science 365, eaav9518 (2019)
David Attwell先生(University College London)との国際共同研究成果
2019年 Temporal progression of Alzheimer’s disease in brains and intestines of transgenic mice.
Neurobiology of Aging 81, 166-176 (2019)
Colin K. Combs先生(University of North Dakota)との国際共同研究成果
2019年 An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model to evaluate only oligomer-induced cognitive decline in Alzheimer’s disease. 
Biochemical and Biophysical Research Communications 515, 462-467 (2019)
2019年 Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model.
Journal of Nuclear Medicine 60, 1787-1793 (2019)
Matthias Brendel先生(LMU Munich)、Jochen Herms先生(DZNE)との国際共同研究成果
2019年 AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation. 
Neurochemistry International 129, 104470 (2019)
2019年 Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells.
Scientific Reports 9, 7508 (2019)
共著者に初めてTakashi Saito(理研の斉藤隆先生)が二人並んだ個人的に記念すべき論文です。
2019年 Tau binding protein CAPON induces tau aggregation and neurodegeneration.
Nature Communications 10, 2394 (2019) (*Corresponding author)
2019年 SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice. 
Nature Communications 10, 1886 (2019)
Mark P. Mattson先生(NIA)との国際共同研究成果
2019年 Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease.
BMC Neuroscience 20, 13 (2019)
2019年 Reducing ADAMTS-3 inhibits amyloid β deposition in APP knock-in mouse.
Biological Pharmaceutical Bulletin 42, 354-356 (2019)
2019年 Aberrant excitatory-inhibitory mechanisms in entorhinal cortex microcircuits during the pathogenesis of Alzheimer’s disease. 
Cerebral Cortex 29, 1834-1850 (2019)
Afia B. Ali先生(University College London)との国際共同研究成果
2018年 Transmission of amyloid β-protein pathology from cadaveric pituitary growth hormone.
Nature 564, 415-419 (2018)
John Collinge先生(University College London)との国際共同研究成果
2018年 Neuroinflammation in mouse models of Alzheimer’s disease.
Clinical and Experimental Neuroimmunology 9, 211-218 (2018) (*Corresponding author)
2018年 T-type calcium channel enhancer SAK3 promotes dopamine and serotonin release in the hippocampus in naive and amyloid precursor protein knock-in mice.
PLoS One 13, e0206986 (2018)
2018年 The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology.
Molecular Psychiatry 20, 2090-2110 (2018)
2018年 Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis. 
BMC Neuroscience 19, 46 (2018)
2018年 Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits.
Hippocampus 29, 3-14 (2018)
Robert J. McDonald先生(University of Lethbridge)との国際共同研究成果
2018年 Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer’s disease.
JCI insight (2018); 3, pii: 121109  
Hui Zheng先生(Huffington Center on Aging)との国際共同研究成果
2018年 Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology.
Nature Communications 9, 1800 (2018)
永田健一研究員(当時:理化学研究所・西道研究室)による次世代医療を見据えた研究成果。ゲノム編集技術を利用し、App遺伝子の3’-UTRに発現制御領域があることを同定しました。斉藤が手がけたApp knockinマウス開発時のネガティブデータの山の中からこの研究の発端が見つかっただけに、あの時の苦労は無駄ではなかったのだと思えました。
2018年 Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice.
Scientific Reports 8, 6264 (2018)
Annemie Van der Linden先生(University of Antwerp)との国際共同研究成果
2018年 Circadian and brain state modulation of network hyperexcitability in Alzheimer’s disease.
eNeuro (2018); 5: pii: ENEURO.0426-17.2018
Iris Oren先生(University of Edinburgh)との国際共同研究成果
2018年 Novel quantitative analysis of spontaneous synaptic events in cortical pyramidal cells reveal subtle parvalbumin-expressing interneuron dysfunction in a knock-in mouse model of Alzheimer’s disease. 
eNeuro (2018); 5: pii: ENEURO.0059-18.2018  
Istvan Mody先生(UCLA)との国際共同研究成果
2018年 The disease-modifying drug candidate SAK3 improves cognitive impairment and inhibits amyloid beta deposition in App knock-in mice.
Neuroscience 377, 87-97 (2018)
2018年 Near-infrared photoactivatable oxygenation catalysts of amyloid protein.
Chem 4, 807-820 (2018)
2018年 Endoplasmic reticulum stress responses in mouse models of Alzheimer’s disease: Overexpression paradigm versus knock-in paradigm.
Journal of Biological Chemistry 293, 3118-3125 (2018)
橋本翔子研究員(理化学研究所・西道研究室)による成果です。ERストレス応答について、App knockinマウスと既存のAPP過剰発現モデルマウスの比較を行いました。
2018年 Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer’s disease model mice.
EMBO Molecular Medicine e8184 (2018)
2018年 Istradefylline reduces memory deficits in aging mice with amyloid pathology.
Neurobiology of Disease 110, 29-36 (2018)
Lennart Mucke先生(UCSF)との国際共同研究成果
2017年 Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheiemr’s disease model mice.
Neuropharmacology 131, 291-303 (2017)
2017年 Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.
Scientific Reports 7, 17762 (2017)
2017年 Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition.
Behavioural Brain Research 364, 431-441 (2019)
Rudi D’Hooge先生(University of Leuven)との国際共同研究成果
2017年 Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.
PLoS One 12, e0182844 (2017)
Gerold Schmitt-Ulms先生(University of Tronto)との国際共同研究成果
2017年 Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer’s disease.
Behavioural Brain Research 336, 177-181 (2017)
Timothy J Sargeant先生(SAHMRI)との国際共同研究成果
2017年 APP mouse models for Alzheimer’s disease preclinical studies.
EMBO J e201797397 (2017)
App knockinマウスの有用性についてまとめた総説です
2017年 Impaired in vivo gamma oscillations in the medial entorhinal cortex of knock-in Alzheimer model.
Frontiers in System Neuroscience 11, article 48 (2017)
Kei Igarashi先生(UC Irvine)との国際共同研究成果
2017年 An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targetting by the ACSA-2 antibody.
Journal of Biological Chemistry 292, 8874-8891 (2017) 
Matthew B. Holt先生(VIB-KU Leuven)との国際共同研究成果
2017年 Tetraspanin 6: a pivotal protein of the Multiple Vesicular Body determining exosome release and lysosomal degradation of Amyloid Precursor protein fragments.
Molecular Neurodegeneration 12:25 (2017)
Bart De Strooper先生(VIB-KU Leuven)との国際共同研究成果
2017年 PLD3 gene and processing of APP.
Nature 541, E1-E2 (2017)
Bart De Strooper先生(VIB-KU Leuven)との国際共同研究成果
2016年 Calpain activation in Alzheimer’s model mice is an artifact of APP and presenilin overexpression.
Journal of Neuroscience 36, 9933-9936 (2016)
齊藤が理研・西道研究室で手掛けた研究です。既存のAPP過剰発現モデルマウスで認められたカルパインの活性化がartificialなものであった可能性を示しました。App knockinマウスの利用を推奨するものです。
2016年 Chronic neuroinflammation underlying pathogenesis of Alzheimer’s disease. 
Springer Book [Chronic Inflammation: Mechanisms and regulation (Editors: Kiyoshi Takatsu and Masayuki Miyasaka)] Chapter 50, p661-671 (2016) (#Corresponding author)  
2016年 HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease.
Scientific Reports 6, 31895 (2016)
2016年 Cognitive deficits in single APP knock-in mouse models.
Neurobiology of Learning and Memory 135, 73-82 (2016)
増田明研究員、糸原重美先生(理研)との共同研究成果です。行動解析ツール INTELLICAGEを用いることで膨大なデータを収集することができます。
2016年 Familial Alzheimer disease mutations in presenilin generate amyloidogenic Aβ peptide seeds.
Neuron 90, 410-416 (2016)
Bart De Strooper先生(VIB-KU Leuven)との国際共同研究成果
2016年 Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.
Biochemical Journal 473, 21-30 (2016)
2015年 GPR3 modulation of the amyloid plaque burden and memory in Alzheimer’s disease.
Science Translational Medicine 7, 309ra164 (2015)
Amantha Thathiah先生(現・Univ. Pittsuburgh)、Bart De Strooper先生(VIB-KU Leuven)との国際共同研究成果
2015年 ScaleS: An optical clearing palette for biological imaging.
Nature Neuroscience 18, 1518-1529 (2015)
濱裕先生、宮脇敦先生との共同研究成果。App knockinマウスを用いた理研内共同研究として最初の論文です。脳の透明化技術・・・凄いです
2015年 Neuronal store-operated calcium entry and mushroom spine loss in APP knock-in mouse model of Alzheimer’s disease.
Journal of Neuroscience 35, 13275-13286 (2015)
Ilya Bezprozanny先生(UT Southwestern Medical Center)との国際共同研究成果
2014年 Single APP knockin mouse models of Alzheimer’s disease.
Nature Neuroscience 17, 661-663 (2014) 
齊藤が理研に入ってすぐから手がけた研究テーマです。次世代型アルツハイマー病モデルマウスの開発に8年、解析に4年の月日がかかった集大成。App knockinマウス開発秘話は涙なくして語れません。世界中で利用して頂けるアルツハイマー病研究のための新たな世界基準マウスモデルになるのではないかと期待しています。
2014年 Autophagy-related protein 7 deficiency in APP transgenic mice decreases Aβ in multivesicular bodies and induces Aβ accumulation in the Golgi.
American Journal of Pathology 185, 305-313 (2014)
スウェーデンからの留学生・Per Nilsson研究員(理研・西道研究室、現・Karolinska Institutet)が手掛けた研究成果です。オートファジーがAβの細胞内輸送や蓄積に関与しているのではないかと考えられます。
2014年 An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease.
EMBO Molecular Medicine 7, 175-189 (2014)
2014年 New mouse model of Alzheimer’s.
ACS Chemical Neuroscience 5, 499-502 (2014)
App knockinマウスの開発、論文化を受けPer Nilsson研究員がまとめたApp knockinマウスに関する最初の総説です。
2013年 Substrate ectodomain is critical for substrate preference and inhibition of β-secretase.
Nature Communications 4, 2529 (2013)
2013年 Aβ secretion and plaque formation depend on autophagy.
Cell Reports 5, 61-69 (2013)
Per Nilsson研究員(理化学研究所・西道研究室)による成果で、オートファジー異常がアミロイド病理に影響することを明らかにしました。
2013年 Human prefoldin inhibits Aβ fibrillation and contributes to formation of non-toxic Aβ aggregates.
Biochemistry 52, 3532-3542 (2013)
座古保先生(当時理研)とKarin Sörgjerd研究員との共同研究成果
2012年 Cell-surface expression of the major Aβ degrading enzyme, neprilysin, depends on phosphorylation by MEK and dephosphorylation by protein phosphatase 1a.
Journal of Biological Chemistry 287, 29362-29372 (2012) (*Co-first author)
2011年 Potent amyloidogenicity and pathogenicity of Aβ43.
Nature Neuroscience 14, 1023-1032 (2011)
齊藤が理研・西道研究室で行った成果です。それまで見過ごされてきたAβペプチドの亜種Aβ43は、実はAβ42よりも高い神経毒性と凝集性を発揮することを明らかにしました。また、Aβ43レベルをモニターすることが病態形成の予測に繋がるのではないかと期待されます。一方で、Aβ43の産生に関与するPresenilin 1-R278I変異の解析からPresenilin biologyの新たな一面を明らかにした大作です!
2010年 Brain endothelial cells produce amyloid β from amyloid precursor protein 770 and preferentially secrete the O-glycosylation form.
Journal of Biological Chemistry 285, 40097-40103 (2010)
2008年 Interleukin-1β up-regulates TACE to enhance β-cleavage of APP in neurons: resulting decrease in Aβ production.
Journal of Neurochemistry 104, 1387-1393 (2008) (*Co-first author)
2006年 A secreted type of β1,6N-acetylglucosaminyltransferase-V (GnT-V), a novel angiogenesis inducer is regulated by γ-secretase.
FASEB Journal 20, 2451-2459 (2006)
2005年 Somatostatin regulates brain amyloid-β peptide Aβ42 through modulation of proteolytic degradation.
Nature Medicine 11, 434-439 (2005)
2003年 Alzheimer’s disease, neuropeptide, neuropeptidase, and amyloid β peptide metabolism.
Science (SAGE-KE) 3, PE1, (2003)
2002年 A secreted type of β1,6N-acetylglucosaminyltransferase-V (GnT-V) induces tumor angiogenesis without mediation of glycosylation.
Journal of Biological Chemistry 277, 17002-17008 (2002)
2001年 Domain-specific mutations of a transforming growth factor (TGF)-β1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-β1.
Journal of Biological Chemistry 276, 11469-11472 (2001)
2000年 Domain-specific mutations in TGFβ1 result in Camurati-Engelmann disease.
Nature Genetics 26, 19-20 (2000)
齊藤が大阪大学での博士課程の時に関与した新川先生、木下先生(長崎大学)との共同研究成果です。この時、関与したELISAによる解析が後の自分の学位論文に関わってくるとは当時は思ってもいませんでした。この論文で初めてCamurati-Engelmann病の原因遺伝子変異がTGF-β1 latent form遺伝子に存在していることが連鎖解析から明らかとなりました。